痕癢與感染的處理
痕癢 鎮靜性抗組織胺並不治療濕疹,亦無抗炎作用;在嚴重發作期或可幫助兒童入睡,但它不是治療。
非鎮靜性抗組織胺僅在同時患有蕁麻疹或過敏性鼻炎時有幫助。
控制濕疹痕癢唯一可靠的方法,就是控制炎症。 真正有幫助的實際措施包括:冷敷、剪短指甲、嬰兒夜間戴棉手套、保持睡房涼爽,以及針對根深柢固搔抓習慣的習慣逆轉訓練。

感染 明確的細菌感染應使用適當抗生素,盡可能以細菌培養結果指導用藥。對未受感染的濕疹常規使用抗生素並無幫助,並會助長抗藥性。稀釋漂白水浴是常見建議,但證據坦白說並不一致——近期分析顯示,當中大部分益處可能來自浸浴本身而非漂白水。此法安全,部分患者覺得有用,但並非必要。
應避免的做法
- 在未證實過敏的情況下嚴格戒口。 這不會改善濕疹,會令兒童面臨營養不良風險,更可能因失去耐受而誘發食物過敏。
- 未受規管的草本或「不含類固醇」乳霜。 標榜天然的產品,屢次被驗出含有未申報的強效類固醇,香港衞生署亦曾就此發出回收公告。若一支乳霜效果驚人而成分不明,這是值得警惕的理由,而非安心的理由。
- 紅色一退就停藥。 可見的泛紅消退後,炎症仍然存在;過早停藥正是發作在數天內捲土重來的原因。
- 反覆使用口服類固醇療程。
- 熱水淋浴,無論當下有多舒服。
第一級治療: 外用抗炎治療
第二級治療: 主動維持治療(常被忽略)
第三級治療: 窄頻NB-UVB 光療
第四級治療: 傳統系統性治療
第五級治療: 生物製劑, 口服JAK抑制劑
Reference:
- Davis DMR, Drucker AM, Alikhan A, et al. AAD guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol. 2023.
- Sidbury R, Alikhan A, Bercovitch L, et al. AAD guidelines of care for the management of atopic dermatitis in adults with phototherapy and systemic therapies. J Am Acad Dermatol. 2023.
- Guidelines Development Panel of the Hong Kong College of Paediatricians. Management of Atopic Dermatitis in Children: 2020 Review. HK J Paediatr. 2021;26:42-57. — the key local reference; cite this prominently.
- Wollenberg A, Kinberger M, Arents B, et al. EuroGuiDerm guideline on atopic eczema. J Eur Acad Dermatol Venereol. (most recent update).
- National Institute for Health and Care Excellence. Atopic eczema in under 12s: diagnosis and management. CG57.
- Leung R, Wong G, Lau J, et al. Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study. Eur Respir J 1997.
- Childhood Wheeze, Allergic Rhinitis, and Eczema in Hong Kong: ISAAC Study from 1995 to 2015. — source of the 21-year local trend data.
- Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993;186:23-31.
- Efficacy and Safety of Lebrikizumab in Combination With Topical Corticosteroids in Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial (ADhere). JAMA Dermatol.
- ARCADIA 1 and ARCADIA 2 — two identically designed pivotal phase III trials enrolling more than 1,700 patients, evaluating nemolizumab administered subcutaneously every four weeks versus placebo with background topical corticosteroids.
- Sanofi. Press release: decision not to submit amlitelimab in atopic dermatitis for global regulatory reviews. Paris, 24 July 2026.
- Simpson EL, Bieber T, Guttman-Yassky E, et al. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis (SOLO 1 and SOLO 2). N Engl J Med. 2016.
- Chalmers JR, et al. BEEP trial: daily emollient during the first year of life for preventing atopic dermatitis. Lancet. 2020. — the negative prevention trial cited in the article.
- Hong Kong Drug Office, Department of Health — verify local registration status of every systemic agent named.
